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KMID : 0378019850280010079
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New Medical Journal
1985 Volume.28 No. 1 p.79 ~ p.87
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A Study on the Distribution of Mast Cells in Human Skin
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崔圭哲/Choi, Kyu Cherl
黃善郁/張信堯/Hwang, Sun Wook/Chang, Shin Yo
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Abstract
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The morphology of the mast cell have, been the subject of extensive studies by numerous investigators. However insufficient data exist in the literature concerning the mast cell population of normal skin. Several works have observed that the density of the mast cell differs with species, and in the same species it varies considerably according to the kinds of tissues and their anatomical locations. Furthermore the number of the mast cells tends to increase in accordance with the increased number of the perivascular cells. So a simple count of the only number of the mast cell could make a wrong interpretation in the diagnosis of mast cell disease. While considering these facts about mast cell distribution in the body, the author thought it would be valuable to clarify standard patterns of mast cell distribution in human skin.
Human skin tissues of 12 different anatomical locations (eyelid, axilla, cheek, lateral thigh, palm, sole, ear, abdomen, back, lateral shin, anterior aspect of forearm and anterior aspect of upper arm) were obtained from 17 autopsies carried out within 24 hours after death. All the autopsy cases had died of accidents without illness including cutaneous diseases. Because mast cells are known to be found mainly around blood vessels and skin appendages, the author measured the population density in those areas not only by counting their numbers per blood vessel and skin appendage units but also by calculating their percentages per the perivascular cells.
The mast cells were counted on the areas around blood vessels, eccrine glands and hair follicles from the section of 6 micron thickness. The results obtained were as follows.
1) The number of the perivascular mast cells was on an average 2.0 per blood vessel and they occupied 8.3% of all perivascular cells.
2) The areas of most frequent incidence of the mast cells were the eyelid and cheek whereas the least frequent areas were the thigh and lower leg.
3) The numbers of perisyringeal and perifollicular areas were both on the average 3. 1 per eccrine gland and hair follicular units.
4) The adolescent showed statistically higher density of mast cells than the elderly.
5) There was no sexual difference in mast cell population.
6) The number of the perivascular mast cells increased proportionally to that of perivascular cells, and the number of the perivascular mast cells showed significant correlation with the number of perisudoglandular mast cells but not with perifollicular mast cells.
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